Clinical Symptoms on Covid-19 Patient According to Pregnancy Status

Authors

  • Anita Rahmawati STIKes Patria Husada
  • Pertiwi Perwiraningtyas Universitas Tribhuwana Tunggadewi Malang

DOI:

https://doi.org/10.48144/jiks.v16i1.1400

Keywords:

Covid-19; Clinical Symptoms; Pregnancy

Abstract

Physiological adaptation in pregnant women may increase the risk of more severe symptoms of Covid-19 than women who are not pregnant but there was not much supporting data. Aim of this study was to compare the severity category between women who are pregnant and not pregnant with positive Covid-19. The study was conducted using a retrospective approach which obtained secondary data from patient medical records after being tested positive for COVID-19 from November 2020 to December 2021. Sample size for the study consisted of 67 women COVID-19 patients who were pregnant and 67 women who were not pregnant. Samples were taken by accidental sampling. Categorization of clinical symptoms of COVID-19 was divided into 5 categories (no symptoms, mild, moderate, severe/severe pneumonia, critical). Data were analysis with the Mann Whitney test. Results showed that there were significant differences in the categories of clinical symptoms between groups of pregnant women and groups of non-pregnant women who were exposed to Covid-19 with a value of p=0.000 (p<0,05). Clinical symptoms in Covid-19 patients who are pregnant more severe than women who are not pregnant. This may be caused by increased levels of coagulation and fibrinolytic factors during pregnancy. It is hoped that the handling of Covid-19 patients, especially pregnant women, will receive more detailed attention to avoid the appearance of more severe clinical symptoms.

References

Y. Liu, H. Chen, K. Tang dan Y. Guo, “Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy.,” The Journal of infection, pp. 4-11, 2020.

V. M. Savasi, F. Parisi, L. Patane, E. Ferrazzi, L. Frigerio, A. Pellegrino, A. Spinillo, S. Tateo, m. Ottoboni, P. Veronese, F. Petraglia, p. Vergani, F. Facchinetti, D. Spazzini dan I. Cetin, “Clinical Findings and Disease Severity in Hospitalized Pregnant Women With Coronavirus Disease 2019 (COVID-19),” Obstet Gynecol, vol. 136, no. 2, pp. 252-258, 2020.

S. Rasmussen, J. Smulian, J. Lednicky, T. Wen dan D. Jamieson, “Coronavirus Disease 2019 (COVID-19) and Pregnancy: what obstetricians need to know.,” Am J Obstet Gynecol , vol. 222, no. 4, pp. 15-26, 2020.

K. R. Biro Komunikasi dan Pelayanan masyarakat, “Sehat Negeriku,” Kementrian Kesehatan RI, 15 September 2021. [Online]. Available: https://sehatnegeriku.kemkes.go.id. [Diakses 2 Agustus 2022].

A. Tanacan, N. Yazihan, S. Erol, A. Anuk, Y. F. Yucel, D. Biriken, E. A. Ozgu, H. Keskin, T. O. Moraloglu dan D. Sahin, “The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study.,” Cytokine, vol. 140, no. 155431, 2021.

Z. Yang, M. Wang, Z. Zhu dan Y. Liu, “Coronavirus disease 2019 (COVID-19) and pregnancy: a systematic review,” The Journal of Maternal-Fetal & Neonatal Medicine, vol. 35, no. 8, pp. 1619 - 1622, 20222.

A. H. Pontoh, “LEVEL OF CHARACTERISTICS (Age, Parity, Education) PREGNANT MOTHER ABOUT THE EVENT OF HIGH RISK PREGNANCY,” Midwifery Journal of Akbid Griya Husada Surabaya, vol. 5, no. 2, pp. 52-59, 2018.

T. Sobotka, Z. Brzozowska, R. Muttarak, K. Zeman dan V. Lego, “Age, gender and COVID-19 infections.,” MedRxiv, pp. 1-16, 2020.

A. S. Posumah, M. F. Wowor dan G. I. Rambert, “Gambaran Faktor Risiko pada Wanita Hamil Trimester 3 yang Terkonfirmasi Positif SARS-CoV-2,” eBiomedik, vol. 9, no. 2, 2021.

L. Rahayu, J. Admiyanti, Y. Khalda , F. Ahda, N. Agistany, S. Setiawati, N. Shofiyanti dan C. Warnaini, “HYPERTENSION, DIABETES MELLITUS, AND OBESITY AS THE MAIN COMORBIDITY FACTORS OF MORTALITY IN COVID-19 PATIENTS: A LITERATURE REVIEW,” JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, vol. 9, no. 1, pp. 90-97., 2021.

W. N. Phoswa dan O. P. Khaliq, “Is pregnancy a risk factor of COVID-19?,” Eur J Obstet Gynecol Reprod Biol, vol. 252, pp. 605-609, 2020.

J. E. Rahmadhani, M. A. Arsyad dan S. Arifudin, “PERBANDINGAN KADAR ENDOTHELIN-1 PADA KEHAMILAN PRIMIGRAVIDA DAN MULTIGRAVIDA,” 8 August 2018. [Online]. Available: https://doi.org/10.31227/osf.io/3uw49.

E. A. Wastnedge, R. M. Reynolds, S. R. V. Boeckel, S. J. Stock, F. C. Denison, J. A. Maybin dan H. O. Critchley, “Pregnancy and COVID-19,” Physiol Rev, vol. 101, no. 1, pp. 303-318, 2021.

Downloads

Published

2023-03-30